发明名称 ACETONE SOLVATE OF DIMETHOXY DOCETAXEL AND METHOD OF OBTAINING IT
摘要 FIELD: chemistry, pharmacology. ^ SUBSTANCE: invention relates to novel compound - acetone solvate of 4-acetoxy-2alpha-benzoyloxy-5beta,20-epoxy-1-hydroxy-7beta, 10beta-dimethoxy-9-oxo-tax-11-ene-13alpha-yl-(2R,3S)-3-tretbutoxycarbonylamino-2-hydroxy-3-phenylpropionate, containing from 5 to 7 wt % of acetone, which has anti-cancer and anti-leukaemia activity, and method of obtaining it by crystallisation in water-alkali solution. ^ EFFECT: obtaining valuable biologically active compound in such form that allows obtaining standard medicinal forms. ^ 5 cl, 1 dwg, 1 ex
申请公布号 RU2342373(C2) 申请公布日期 2008.12.27
申请号 RU20060113122 申请日期 2004.09.16
申请人 AVENTIS FARMA S.A. 发明人 DID'E EHRIK;PERREHN MARK-ANTUAN
分类号 C07D305/14;A61K31/58 主分类号 C07D305/14
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