发明名称 COMPOSITION AND METHOD OF PREPARING MICROPARTICLES OF WATER-INSOLUBLE SUBSTANCES
摘要 Compositions and procedures that yield sub-micron and micron-size stable particles of water-insoluble or poorly soluble drugs or other industrially useful insoluble compounds are prepared using combinations of natural or synthetic phospholipids, a charged surface modifier such as a highly purified charged phospholipid and a block copolymer coated or adhered onto the surfaces of the water insoluble-compound particles. The combination of charged surface modifier and block copolymer allows the formation and stabilization of the sub-micron and micron size compound particles - stabilized by the charged phospholipid to provide electrostatic stabilization and the block copolymer to provide steric stabilization - and therefore prevents these particles from particle growth, aggregation or flocculation.
申请公布号 CA2326456(C) 申请公布日期 2008.12.23
申请号 CA19992326456 申请日期 1999.03.29
申请人 RTP PHARMA INC. 发明人 PACE, GARY W.;KHAN, SHEEMA
分类号 A61K9/51;A61K9/14;A61K9/16;A61K47/10;A61K47/24 主分类号 A61K9/51
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