发明名称 |
COMPOSITION AND METHOD OF PREPARING MICROPARTICLES OF WATER-INSOLUBLE SUBSTANCES |
摘要 |
Compositions and procedures that yield sub-micron and micron-size stable particles of water-insoluble or poorly soluble drugs or other industrially useful insoluble compounds are prepared using combinations of natural or synthetic phospholipids, a charged surface modifier such as a highly purified charged phospholipid and a block copolymer coated or adhered onto the surfaces of the water insoluble-compound particles. The combination of charged surface modifier and block copolymer allows the formation and stabilization of the sub-micron and micron size compound particles - stabilized by the charged phospholipid to provide electrostatic stabilization and the block copolymer to provide steric stabilization - and therefore prevents these particles from particle growth, aggregation or flocculation.
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申请公布号 |
CA2326456(C) |
申请公布日期 |
2008.12.23 |
申请号 |
CA19992326456 |
申请日期 |
1999.03.29 |
申请人 |
RTP PHARMA INC. |
发明人 |
PACE, GARY W.;KHAN, SHEEMA |
分类号 |
A61K9/51;A61K9/14;A61K9/16;A61K47/10;A61K47/24 |
主分类号 |
A61K9/51 |
代理机构 |
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