发明名称 |
Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers |
摘要 |
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (-)-2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.
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申请公布号 |
US7468436(B2) |
申请公布日期 |
2008.12.23 |
申请号 |
US20040795046 |
申请日期 |
2004.03.05 |
申请人 |
EMORY UNIVERSITY |
发明人 |
LIOTTA DENNIS C.;SCHINAZI RAYMOND F.;CHOI WOO-BAEG |
分类号 |
C07D411/04;A61K31/506;A61K31/513;A61K31/52;A61P31/12;C07D307/00;C07D327/04;C07D405/04;C07D407/04;C07D473/00;C07H19/00;C07H19/06;C07H19/10 |
主分类号 |
C07D411/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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