| 发明名称 |
COMBRETASTATIN A-4 PHOSPHATE PRODRUG SALTS WITH NITROGEN-CONTAINING COMPOUNDS |
| 摘要 |
Provided herein are novel and useful combretastatin A-4 prodrug salts that increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological conditions, and which produce physiologically tolerable products as a result of the regeneration o f combretastatin A-4.
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| 申请公布号 |
CA2422359(C) |
申请公布日期 |
2008.12.23 |
| 申请号 |
CA20012422359 |
申请日期 |
2001.09.12 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
DAHLHEIM, CHARLES E.;HUANG, YANDE;DALI, MANISHA M.;DALI, MANDAR V.;VENIT, JOHN J.;TEJWANI, RAVINDRA W. |
| 分类号 |
C07F9/12;A61K31/66;A61P35/00;C07C211/14;C07C215/10;C07C215/12;C07C215/40;C07C229/08;C07C229/26;C07C279/14;C07D233/54;C07D233/61;C07D233/64 |
主分类号 |
C07F9/12 |
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