发明名称 |
Process for the preparation of chiral beta amino acid derivatives by asymmetric hydrogenation |
摘要 |
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
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申请公布号 |
US7468459(B2) |
申请公布日期 |
2008.12.23 |
申请号 |
US20050549425 |
申请日期 |
2005.09.15 |
申请人 |
MERCK & CO., INC. |
发明人 |
XIAO YI;ARMSTRONG, III JOSEPH D.;KRSKA SHANE W.;NJOLITO EUGENIA;RIVERA NELO R.;SUN YONGKUI;ROSNER THORSTEN |
分类号 |
C07C211/00;B01J31/22;B01J31/24;C07C227/16;C07C231/12;C07C237/20;C07D249/00;C07D487/04 |
主分类号 |
C07C211/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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