A NOVEL PROTEIN KINASE C THERAPY FOR THE TREATMENT OF ACUTE LUNG INJURY

摘要

The present invention provides an aerosol formulation of a dPKC inhibitor. The dPKC inhibitor can be, for example, a peptide. The present invention also discloses a method of preventing acute pulmonary cell injury associated with trauma, ALI or ARDS and a method of inhibiting an inflammatory response in pulmonary cells by inhibiting the activity of dPKC. The invention also provides a method of treating a pulmonary disease with an aerosol formulation of a dPKC inhibitor to inhibit neutrophil activity.