| 发明名称 |
A NOVEL PROCESS FOR THE PREPARATION OF 3-AMINO-PENTAN-1,5-DIOL |
| 摘要 |
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-l,5-diol (2), which is useful for the preparation of 6-(2,4- difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H- pyrido[2,3-d]pyrimidine-7-one (1) a MAP -kinase inhibitor useful in the treatment of rheumatoid arthritis.
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| 申请公布号 |
CA2690327(A1) |
申请公布日期 |
2008.12.18 |
| 申请号 |
CA20082690327 |
申请日期 |
2008.06.06 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
CLEARY, THOMAS P.;JI, YAOHUI;LEE, GARY R.;RAWALPALLY, THIMMA;SARMA, KESHAB |
| 分类号 |
C07C213/02;C07C215/10;C07C269/04;C07C269/06;C07C271/16;C07C271/22 |
主分类号 |
C07C213/02 |
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