EXTENDED RELEASE FORMULATION AND METHOD OF TREATING ADRENERGIC DYSREGULATION
摘要
A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a a2-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours to a subject having a steady state plasma concentration of the a2-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.
申请公布号
WO2008154339(A2)
申请公布日期
2008.12.18
申请号
WO2008US66036
申请日期
2008.06.06
申请人
ADDRENEX PHARMACEUTICALS, INC.;HORACEK, H., JOSEPH;HE, MIN, MICHAEL;KHAYRALLAH, MOISE, A.
发明人
HORACEK, H., JOSEPH;HE, MIN, MICHAEL;KHAYRALLAH, MOISE, A.