The invention provides a novel chemical series of formula (I), as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and negatively modulating the a5 subtype of GABAA, and use of the compound of formula (I) in the manufacture of a medicament for the treatment of GABAA receptor associated disorders. The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).
申请公布号
WO2008154447(A1)
申请公布日期
2008.12.18
申请号
WO2008US66211
申请日期
2008.06.06
申请人
HELICON THERAPEUTICS, INC.;KAPLAN, ALAN, P.;GUPTA, VARSHA;WASLEY, JAN, W., F.
发明人
KAPLAN, ALAN, P.;GUPTA, VARSHA;WASLEY, JAN, W., F.