ASSAYS FOR DETECTING NATIVE-STATE PROTEINS AND IDENTIFYING COMPOUNDS THAT MODULATE THE STABILITY OF NATIVE-STATE PROTEINS

摘要

This invention relates to assays for detecting native-state proteins and to screening methods to identify compounds that modulate the stability of the native-state of proteins. Compounds identified by such screens can be used to treat diseases associated with protein misfolding, such as Alzheimer's Disease, familial amyloidotic polyneuropathies, and lysosomal storage diseases.