发明名称 |
ENGINEERED TOEHOLD REACTIONS AND NETWORKS |
摘要 |
A catalytic system and method of catalyzing reactions that uses a novel toehold exchange mechanism that allows a specified input to catalyze the release of a specified output, which in turn can serve as a catalyst for other reactions is provided. This toehold exchange catalyst system, which can be driven forward by the configurational entropy of the released molecule, provides an amplifying circuit element that is simple, fast, modular, composable, and robust. Using this toehold exchange catalyst system it has been possible to construct and characterize several circuits that amplify nucleic acid signals, including a feed-forward cascade with quadratic kinetics and a positive feedback circuit with exponential growth kinetics.
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申请公布号 |
WO2008097929(A3) |
申请公布日期 |
2008.12.18 |
申请号 |
WO2008US52959 |
申请日期 |
2008.02.04 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;ZHANG, DAVID;TURBERFIELD, ANDREW, J.;WINFREE, ERIK |
发明人 |
ZHANG, DAVID;TURBERFIELD, ANDREW, J.;WINFREE, ERIK |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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