发明名称 |
NEUROPROTECTIVE COMPOSITIONS AND METHODS |
摘要 |
Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keapl, a negative regulator of the transcription factor Nrf2, and prevent Keapl -mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keapl /Nrf2 complex.
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申请公布号 |
WO2008108825(A3) |
申请公布日期 |
2008.12.18 |
申请号 |
WO2007US21748 |
申请日期 |
2007.10.10 |
申请人 |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH;LIPTON, STUART, A.;SATOH, TAKUMI |
发明人 |
LIPTON, STUART, A.;SATOH, TAKUMI |
分类号 |
A01N33/02;A61K31/13 |
主分类号 |
A01N33/02 |
代理机构 |
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代理人 |
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地址 |
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