摘要 |
Provided herein are methods for treating a subject suffering from phenylk etonuria by administering a phenylalanine hydroxylase ("PAH") and/or a pheny lalanine ammonia lyase ("PAL") to the subject under conditions effective to deliver the phenylalanine 4-hydroxylase and/or PAL to the subject's small in testine. Also provided are methods for increasing the therapeutic activity o f a phenylalanine 4-hydroxylase by thiolating the phenylalanine 4-hydroxylas e. In addition, provided are oral dosage forms that include a phenylalanine 4-hydroxylase and/or a PAL and an enteric coating.
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