发明名称 |
Antibody Specific for Human 4-1BB Receptor |
摘要 |
The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes derived from cDNA 4-1BB. A fusion protein for detecting cell membrane ligands to human receptor protein H4-1BB was developed. It comprises the extracellular portion of the receptor protein H4-1BB and a detection protein (alkaline phosphatase) bound to the portion of the receptor protein H4-1BB. B-cells that have expressed a ligand to receptor protein H4-1BB can be treated with cells that have expressed receptor protein H4-1BB and B-cell proliferation may be induced. The use of H4-1BB to block H4-1BB ligand binding has practical application in the suppression of the immume system during organ transplantation. A monoclonal antibody against H4-1BB can be used to enhance T-cell proliferation by treating T-cells that have expressed receptor protein H4-1BB with the anti H4-1BB monoclonal antibody. Tumors transfected with H4-1BBL may be capable of delivering antigen-specific signals as well as the co-stimulatory signals and can be killed by human cytotoxic T lymphocytes.
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申请公布号 |
US2008312418(A1) |
申请公布日期 |
2008.12.18 |
申请号 |
US20070873784 |
申请日期 |
2007.10.17 |
申请人 |
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION |
发明人 |
KWON BYOUNG S. |
分类号 |
C07K16/28;G01N33/53;A61K38/00;C07K14/705;C07K14/715;C07K14/725;C12N5/10;C12N5/12;C12N15/09;C12N15/12;C12P21/02;C12P21/08;G01N33/566;G01N33/577 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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