17BETA-CYANO-18A-HOMO-19-NOR-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE

摘要

The 17ß-cyano-18a-homo-19-nor-androst-4-ene derivatives of the present in vention have gestagenic activity. They have the general chemical formula (1) , in which Z is selected from the group comprising O, two hydrogen atoms, NO R and NNHSO2R, wherein R is hydrogen or C1-C4 alkyl, R4 is hydrogen or halog en and in addition either: R6a, R6b together form methylene or 1,2 ethanediy l or R6a is hydrogen and R6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R7 is selected from the group comprising h ydrogen, C1-C4 alkyl, C2-C3 alkenyl and cyclopropyl, or: R6a is hydrogen and R6b and R7 together either form methylene, or are omitted, whereby a double bond is formed between C6 and C7, R9 andR10 are hydrogen, or are omitted, w hereby a double bond is formed between C9 and C10, R15 and R16 are hydrogen or together form methylene, R17 is selected from the group comprising hydrog en, C1-C4 alkyl and aIIyI, at least one of the substituents R4, R6a, R6b, R7 , R15, R16 and R17 not being hydrogen, or R6b and R7 being omitted, whereby a double bond is formed between C6 and C7,or are omitted, whereby a double b ond is formed between C1 and C2. The derivatives also comprise the solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts of the aforem entioned substances.