PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT

摘要

The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Abl, Aurora-A, B-raf, Bcr-Abl, BRK, Blk, Bmx, cKit, c-RAF, cSRC, CSK, FLT1, Fms, Fyn, JAK2, KDR, Lck, Lyn, PDGFRa, PDGFRß, PKCa, p38 (p38 MAP kinase, SAPK2a), Src, SIK, Syk, Tie2 and TrkB kinases. Formula (I) wherein L is attached at any position on Ring E and is -NR4(CO)CR2)n or - (CO)NR4(CR2)ni X is a bond or C(O); Y is a 5-7 membered carbocyclic ring, aryl, heterocyclic ring or heteroaryl;