发明名称 |
SOLUBLE HER2 AND HER3 SPLICE VARIANT PROTEINS, SPLICE-SWITCHING OLIGONUCLEOTIDES, AND THEIR USE IN THE TREATMENT OF DISEASE |
摘要 |
<p>Soluble epidermal growth factor receptors 2 and 3 (HER2 and HER3) splice variant proteins with HER2 and HER3 antagonist activity and anti-proliferative properties, as well as the corresponding nucleic acids, are provided for treatment of proliferative diseases, in particular cancer. Also provided are compositions and methods for inducing expression of these splice variants, including splice switching oligonucleotides that modulate splicing of pre-mRNA that codes for these receptors.</p> |
申请公布号 |
WO2008153933(A2) |
申请公布日期 |
2008.12.18 |
申请号 |
WO2008US07111 |
申请日期 |
2008.06.06 |
申请人 |
AVI BIOPHARMA, INC.;KOLE, RYSZARD;SAZANI, PETER;WAN, JING |
发明人 |
KOLE, RYSZARD;SAZANI, PETER;WAN, JING |
分类号 |
A61K38/17 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|