发明名称 |
METHODS AND COMPOSITIONS FOR TREATING T-CELL LEUKEMIA |
摘要 |
<p>The present invention relates to compositions and methods that may be used to diagnose and treat cancer, particularly T-cell leukemia. According to one preferred embodiment of the present invention, methods are provided for determining whether reducing or blocking NOTCH-1 activation will be effective to treat, prevent, or ameliorate the effects of a cancer in a patient, including T-cell leukemia, myeloleukemia, neuroblastoma, breast cancer, and ovarian cancer. The methods generally include determining if the patient harbors one or more mutations in a PTEN coding region. In particular, the methods may be used to determine whether reducing or blocking NOTCH-1 activation, with one or more ?-secretase inhibitors, will be effective to treat, prevent, or ameliorate the effects of a cancer in a patient.</p> |
申请公布号 |
WO2008094709(A3) |
申请公布日期 |
2008.12.18 |
申请号 |
WO2008US01434 |
申请日期 |
2008.02.01 |
申请人 |
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;FERRANDO, ADOLFO, A.;PALOMERO, TERESA;SULIS, MARIA, LUISA |
发明人 |
FERRANDO, ADOLFO, A.;PALOMERO, TERESA;SULIS, MARIA, LUISA |
分类号 |
C12Q1/68;C07H21/04;C12N9/00;C12P19/34;G01N33/00 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|