| 发明名称 |
NUCLEIC ACID FRAGMENT AND POLYPEPTIDE FRAGMENT DERIVED FROM MYCOBACTERIUM TUBERCULOSIS |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To obtain a new antigen that is effective as a component for a subunit vaccine against Mycobacterium tuberculosis or a component for a diagnostic composition for detecting infection with Mycobacterium tuberculosis. <P>SOLUTION: The polypeptide has new several specific amino acid sequences derived from Mycobacterium tuberculosis. Its immunologically active fragment is obtained. The gene encodes the fragment. The immunological composition such as vaccines is obtained. The skin test reagent contains the peptide. Especially a fusion product between ESAT-6 and MPT59 has a superior immunogenicity compared to each of the unfused protein, respectively. <P>COPYRIGHT: (C)2009,JPO&INPIT |
| 申请公布号 |
JP2008301817(A) |
申请公布日期 |
2008.12.18 |
| 申请号 |
JP20080131389 |
申请日期 |
2008.05.19 |
| 申请人 |
STATENS SERUM INST |
发明人 |
ANDERSEN PETER;SKJOET RIKKE LOUISE VINTHER;ROSENKRANDS IDA;WELDINGH KARIN;RASMUSSEN PETER BIRK;OETTINGER THOMAS;FLORIO WALTER |
| 分类号 |
C12N15/09;A61K31/711;A61K38/00;A61K39/00;A61K39/04;A61K39/104;A61K39/112;A61P31/04;A61P31/06;A61P37/02;A61P43/00;C07K14/35;C07K16/12;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/31;C12P21/02;C12P21/08;C12Q1/68;G01N33/53;G01N33/569 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
