| 摘要 |
A transdermal medicament patch ( 18,0168) includes a substrate(32, 172) having a therapeutic face (40, 180) configured for disposition against the skin (102), an adhesive on the therapeutic face (40, 180), a planar medicament matrix (46, 188) covering a portion of the therapeutic face (46,188), and a release liner (41, 182) covering the portion of therapeutic face (40, 180) not obscured by the medicament matrix (46, 188). An aperture (44, 186) through the release liner (41, 182) affords access to the medicament matrix (46, 188). An active electrode (54, 110, 120, 130, 140, 150, 210, 230, 250, 270, 290) positioned between the medicament matrix (46, 188) and the therapeutic face (40, 180) includes an electrically conductive backing layer (56, 142, 152, 212, 232, 252, 272, 292) positioned against the therapeutic face (40, 180) and a pH-control layer (58, 132, 146, 156, 216, 236, 256, 276, 296) that moderates changes in hydrogen-ion concentration covering less than all of the therapeutic face (40, 180). One active electrode design criterion relates the size of the pH-control layer to the size of the backing layer; another relates the size of the portion of the backing layer not covered by the pH-control layer to the size of the pH-control layer. |
