NOVEL PROTEIN FUSION/TAG TECHNOLOGY

摘要

The present invention relates to fusion molecules comprising at least one first purification domain and a molecule of interest, wherein the purification domain is selected from the group consisting of a kringle domain and a staphylocoagulase D2 domain. The present invention further relates to methods of purifying a molecule of interest using the fusion molecules of the invention. Also provided is a method of making an antibody using the fusion molecules of the invention, wherein the purification domain is a kringle domain. In addition, the present invention provides for vaccines which have reduced immunoreactivity and which comprise a fusion molecule having a kringle domain and an immunogenic domain.