NEW ADENOSINE-5'-CARBOXYLIC ACID DERIVATIVES

摘要

1295228 Adenosine derivatives BOEHRINGER MANNHEIM GmbH 8 July 1971 [14 July 1970] 32182/71 Heading C2C Novel compounds of Formula I (in which each of R 1 and R 2 is H, OH, NH 2 , C 1-6 alkyl, C 2-6 alkenyl, optionally N-alkylated C 1-6 aminoalkyl, cycloalkyl, hydroxyalkyl or piperidino or R 1 and R 2 together represent a C 4-7 alkylene radical which can be interrupted by an oxygen or sulphur atom or an imino, alkylimino or arylimino radical and Z represents two hydrogen atoms or a C 2-6 alkylidene radical) and pharmacologically compatible acid addition salts thereof, are prepared by reacting a reactive derivative of a carboxylic acid of the Formula II with a compound of formula R 1 -NH-R 2 and optionally converting the product obtained into a pharmacologically compatible acid addition salt. 21,31 - o - Isopropylidene - adenosine - 51 - carboxylic acid chloride is prepared by reacting the corresponding acid with thionyl chloride. Pharmaceutical compositions for oral or parenteral administration, comprise a compound of Formula I or a pharmacologically acceptable acid addition salt thereof, together with a pharmaceutical carrier or diluent. The active compounds exhibit a strong circulatory activity.