| 摘要 |
A process for 21-fluorination of 20-oxo-steroids, wherein a steroid of the partial formula WHEREIN X represents a reactive esterified hydroxyl group that is different from the fluorine atom, Y represents a hydrogen atom or a lower aliphatic radical, Z represents a geminal hydrocarbon radical of aliphatic character, and St represents the optionally substituted residual part of the steroid skeleton, is treated with an agent containing radical-anions, such as lithium-biphenyl, and with perchloryl fluoride, affords final products free of difluorinated side-products.
|
