发明名称 |
SYNTHESIS OF DIMERIC INDOLE ALKALOIDS |
摘要 |
<p>A concerted process for the synthesis of a dimer consisting of an indole unit and a dihydroindole unit possessing natural stereochemistry which comprises: (a) forming an N-oxide intermediate from said indole unit; (b) treating said N-oxide indole intermediate in the presence of acetic anhydride or halogenated derivative thereof to effect a Polonovski-type fragmentation reaction; (c) without isolating the N-oxide indole intermediate and at a temperature of about -10 DEG C. to +10 DEG C., coupling said reaction product with a dihydroindole unit in the presence of acetic anhydride or a halogenated derivative thereof at a low temperature of about -10 DEG C. to +10 DEG C. under inert conditions; and (d) subsequently reducing the immonium nitrogen on the indole unit by reacting with aqueous alkali metal borohydride to produce a dimer.</p> |
申请公布号 |
IE43226(L) |
申请公布日期 |
1976.11.30 |
申请号 |
IE19760001051 |
申请日期 |
1976.05.18 |
申请人 |
UNITED STATES DEPARTMENT OF COMMERCE |
发明人 |
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分类号 |
C07D471/20;C07D519/04;(IPC1-7):C07D519/04 |
主分类号 |
C07D471/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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