| 摘要 |
A nitrile is reacted with a 2-aminoethylhydrazine in the presence of transition metal salts or of elemental sulphur as catalyst. The new 3-diarylethyl-tetrahydro-1,2,4-triazines thus obtained, of formula <IMAGE> in which m = 0, n = 1, R is a hydrogen atom or a methyl or acetyl group, R1 is a hydrogen atom or a methyl group, A and B independently represent a naphthyl, 1,3-benzodioxol-5-yl or phenyl group or a phenyl group substituted by one or two fragments chosen from the following: lower alkyl, lower alkoxy, halo and naphthyl, provided that A is not a phenyl group when B is a phenyl or naphthyl group, and their pharmaceutically acceptable salts can be used as anxiolytic medicaments. |
