1 alpha ,3 beta -Dihydroxy-steroid-5-enes from 1 alpha ,2 alpha -epoxy-steroid-4,6-dien-3-ones

摘要

Improved yields of 1 alpha ,3 beta -dihydroxy-steroid-5-enes are obtained by the addition of the alkali metal/liquid ammonia reduction products of 1 alpha ,2 alpha -epoxy-4,6-dien-3-one steroids to a quenching agent such as liquid ammonia/ammonium chloride mixture. Specific steroids reduced by these procedures include 1 alpha ,2 alpha -epoxycholesta-4,6-dien-3-one and 25-hydroxy-1 alpha ,2 alpha -epoxycholesta-4,6-dien-3-one.