| 摘要 |
Anti-thrombotic pharmaceutical compositions comprise a pyridine derivative of the formula: <IMAGE> in which: X represents oxygen or sulfur; R represents a phenyl or benzoyl group which may be substituted by more halogen, straight- or branched-chain C1-6 alkyl or alkoxy groups, nitro, amino, sulfonylamino, carboxy, C1-6 alkoxycarbonyl, cyano, phenyl, hydroxy C1-6 alkyl, methylene-dioxy or ethylene-dioxy groups: or R may be an alpha -naphthyl or thienyl group; R1 represents hydrogen, halogen, hydroxy, a straight- or branched-chain C1-6 alkyl or alkoxy group or a phenyl group; R<1> represents a C1-6 alkyl group; and n is an integer from 1 to 15; wherein R1 may have different meanings in each radical CHR1 when n is greater than 1, or a pharmaceutically acceptable acid addition salt or quaternary ammonium derivative thereof: together with a beta-receptor blocking agent (e.g. propranolol metoprolol, atenolol, acebutolol, pindalol,timolol, bupranol, bunolol, alprenol, and oxprenolol). The preferred compound (I) is ticlopidine hydrochloride. |
