发明名称 |
PROCESS FOR PREPARING A BIOLOGICAL COMPOSITION FOR USE AS A REFERENCE CONTROL IN DIAGNOSTIC ANALYSIS |
摘要 |
<p>A process for making a biological composition for use as a blood serum reference composition in diagnostic analysis. The process comprises: (a) adding calcium to citrated plasma and mixing well to form decitrated plasma; (b) adding thrombin to the decitrated plasma and mixing well to form a clot of fibrin; (c) performing at least one freeze-thaw routine on the clot to cause the fibrin to contract; (d) removing the fibrin to thereby obtain serum; (e) molecular washing and ultrafiltering the serum and thereby obtaining concentrated serum; and (f) adding to the concentrated serum at least one alkylene polyol having from 2-5 carbon atoms in an amount such that said composition's non-biological component comprises from about 40 to about 85 weight percent water And from about 15 to about 60 weight percent of said alkylene polyol.</p> |
申请公布号 |
CA1106759(A) |
申请公布日期 |
1981.08.11 |
申请号 |
CA19790331130 |
申请日期 |
1979.07.04 |
申请人 |
BECKMAN INSTRUMENTS, INC. |
发明人 |
LOUDERBACK, ALLAN L. |
分类号 |
G01N33/48;A61K35/16;G01N33/483;G01N33/86;G01N33/92;G01N33/96;(IPC1-7):61K35/16;01N33/48 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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