| 摘要 |
Novel hydroxyethylidene-cyanoacetanilides of the formula Ia, and their tautomeric form Ib, are prepared by reacting a cyanoacetanilide, which is appropriately substituted in the benzene ring, in the presence of an anhydride of a lower fatty acid, to give an alkoxyethylidene-cyanoacetanilide, and then hydrolysing the latter compound. The alkoxyethylidene-cyanoacetanilide, which is obtained as an intermediate, can, prior to the hydrolysis, be reacted with a secondary amine to give a dialkylaminoethylidene-cyanoacetanilide. The latter route is suitable, in particular, for compounds having substituents which are sensitive to acid or alkali, since the hydrolysis readily proceeds under mild conditions. The symbols in the formulae Ia and Ib have the meaning given in Patent Claim 1. The compounds of the formulae Ia and Ib, and their physiologically tolerated salts, exhibit strong antiinflammatory, analgesic, anthelmintic, antimycotic and fungicidal effects. Even the alkoxyethylidene-cyanoacetanilides and the dialkylaminoethylidene-cyanoacetanilides which are obtained as intermediates display antiinflammatory and analgesic effects. <IMAGE>
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