| 摘要 |
A 2-thiophene acetic acid compound of formula (I): <IMAGE> in which: R represents an alkyl radical of 1 to 4 carbon atoms; and R1, R2 and R3 are the same or different and each represents a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a halogen atom; is prepared by reacting a haloalkylthiophene of formula (III): <IMAGE> in which R, R1, R2 and R3 are as defined above and Hal represents a halogen atom, with a cyanide of formula A-CN in which A represents an alkali metal atom, an alkaline-earth metal equivalent or a hydrogen atom to produce a cyanoalkylthiophene of formula (IV): <IMAGE> in which R, R1, R2 and R3 are as defined above, and hydrolysing the cyanoalkylthiophene of formula (IV) to the 2-thiophene acetic acid compound of formula (I). The compound of formula (I) is an intermediate in the production of pharmaceuticals. |
