Novel carbacyclin esters, process for the preparation thereof, and their use as medicinal agents

摘要

Carbacyclin esters of Formula I <IMAGE> (I) wherein R1 is an unsubstituted or substituted aromatic residue, R2 is a free or functionally modified hydroxy group, R3 is an alkyl or cycloalkyl group, or an optionally substituted aryl group, or a heterocyclic group, X is an oxygen atom or the group -CH2-, A is a -CH2-CH2-, trans-CH=CH-, or -C 3BOND C-group, W is a free or functionally modified hydroxymethylene group or a free or functionally modified <IMAGE> wherein the OH-group can be in the alpha - or beta -position D is the group <IMAGE> a straight-chain saturated alkylene group of 1-5 carbon atoms, a branched, saturated or a straight-chain or branched, unsaturated alkylene group of 2-5 carbon atoms, which groups can optionally be substituted by fluorine atoms, E is a direct bond, a -C 3BOND C-group, or a -CR4=CR5- group wherein R2 and R5 mean a hydrogen atom or an alkyl group of 1-5 carbon atoms; are useful as blood-pressure-lowering agents, inter alia.