| 摘要 |
NEW MATERIAL:A compound shown by the formula I (R1 is methyl or ethyl; R2-R4 are H, the same lower alkyl as that of R1, phenyl, or substituted phenyl). USE:An analgesic by inhibiting an enzyme to decompose opioid. PREPARATION:For example, a trihalogenogermylpropionic acid derivative shown by the formula II (X is halogen) is reacted with a Grignard reagent shown by the formula R1MgBr, etc. to give a trialkylgermylpropionic acid derivative, this compound is treated with bromine, etc., to scissor a Ge-R1 bond and germanium is brominated to give a monobromoform derivative shown by the formula III. Then, this compound is hydrolyzed with water, neutralized with an aqueous solution of sodium hydroxide, water is distilled away, precipitated crystal is extracted with acetone, acetone is distilled away and the resulting substance is recrystallized with benzene, etc., to give a compound shown by the formula I.
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