摘要 |
3-(4-Fluorophenoxy)-1-propanol has been prepared by reacting 4-fluorophenol with either 1-chloro-3-hydroxypropane or 1-bromo-3-hydroxypropane. The novel product so obtained is useful as an intermediate in the synthesis of 6-fluoro-4-chromanone, which is itself a key intermediate in the production of (4S)-6-fluoro-spiro-[chroman-4,4 min -imidazolidine]-2 min ,5 min -dione-(sorbin ol). The latter final product is of pharmaceutical value as an agent for the control of certain chronic diabetic complications. |