| 摘要 |
PURPOSE:To obtain the titled compound in high yield and optical purity with simple procedure, by carrying out the optical resolution of DL-alpha-amino-epsilon- caprolactam using an optically active N-benzoyl-methionine as an optical resolution agent. CONSTITUTION:1mol of DL-alpha-amino-epsilon-caprolactam (abbreviated as DL-ACL) is made to contact with 0.1-2.0mol of N-benzoyl-L-methionine and N-benzoyl-D- methionine used as an optical resolution agent at 0-80 deg.C preferably in water. A hardly soluble diastereomer salt is crystallized from the resultant solution e.g. by cooling the solution. The salt is separated by a solid-liquid separation process such as filtration, centrifugal separation, etc., and is subjected to optical resolution e.g. by contacting with a cation exchange resin in an aqueous solvent. The resolution agent is separated and the cation exchange resin is eluted with NH3, etc., to obtain D-ACL or L-ACL. USE:Intermediate for L-lysine or raw material of pharmaceuticals such as hypotensor.
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