| 摘要 |
<p>A novel tumor-associated antigen expressed by normal breast tissue and breast carcinoma is disclosed. The antigen, characterized by monoclonal antibody YBY088, is a protein having molecular weight components within the ranges of about 68,000 to about 80,000, about 40,000 to about 48,000, about 28,000 to about 32,000, and about 16,000 to about 19,000 and isoelectric points, with respect to such molecular weight components, within the ranges of about pH 8.0 to about pH 8.8, about pH 5.2 to about pH 5.8, about pH 6.2 to about pH 6.8, and about pH 8.0 to about pH 8.8. Antibodies directed against the antigen, methods for their production and diagnostic and therapeutic uses therefor are also provided.</p> |
