| 摘要 |
<p>PURPOSE:To prepare the titled compound useful as an intermediate of antibiotics, economically in an industrial scale, by subjecting a specific beta-lactam derivative to oxymercuration-demercuration reaction, oxidative decarbonation reaction, dearylmethylation reaction, etc. CONSTITUTION:The beta-lactam derivative of formula II (R3 is H, alkyl-substituted silyl, alkyloxycarbonyl, alkyl, etc.) is prepared from the beta-lactam derivative of formulaI(R1 is H, alkyl, mono- or diaryl-alkyl, aryl or protecting group; R2 is mono- or diarylmethyl) by an arbitrary combination of the following three reactions comprising (A) oxymercuration-demercuration reaction, (B) oxidative decarbonation reaction with lead tetraacetate, and (C) removal of mono- or diarylmethyl, which may be combined with various conventional reactions for the removal or introduction of protecting group.</p> |
