| 摘要 |
PURPOSE:To obtain an external preparation for skin preventing aging of ski, providing smooth, moist and young skin free from wrinkles, containing a compound having a specific basic skeleton of guanosine 3',5'-cyclic-phosphate compound, etc. CONSTITUTION:An external preparation for skin containing a compound, preferably a compound shown by formula II (R1-R4 are H, 1-221C acyl or 1-22C alkyl; X is H, halogen, mercapto, thio-containing group, amino, aminoalkyl or OH; M is H or salt-forming cation), having a basic skeleton shown by formula I, as an active ingredient. The amount of the active ingredient contained in the external preparation for skin is 0.001-5wt.%, especially 0.01-2wt.%. When the external preparation is applied to the skin, excellent effects are shown as a result of multiplication promoting action of corium fibroblast, production promoting action of collagen elastic fiber, controlling action on melanin dyestuff metabolism, etc., by percutaneous absorption. |
