| 摘要 |
NEW MATERIAL:The compound of formula I [X is H or arenesulfonyl; R is H, acyl or 2-(arenesulfonyl)-1,1-diazanediylalkyliden-1-yl]. EXAMPLE:4-Cyanomethyloxyindole. USE:A synthetic raw material for 5-oxa-1,3,4,5-tetrahydrobenz-[cd]indole derivative of formula II (Y is H or lower alkyl) having antitumor activity. PREPARATION:A compound of formula I wherein R and X are H can be produced by the thermal reaction of 4-hydroxyindole of formula III with a halogenonitrile in a solvent such as methyl ethyl ketone in the presence of a base such as K2CO3 at 60-80 deg.C. The produced compound can be converted to another compound of formula I wherein X is H and R is acyl by the Vilsmeier-Haack reaction or Friedel-Crafts reaction using an acid chloride as a reagent.
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