摘要 |
The invention refers to the preparation of diosmine octakis (hydrogen sulfate) aluminium, a new derivative of diosmine, by reaction of diosmine with a sulfating agent, such as sulfur trioxide-pyridine complex, sulfur trioxide-trimethylamine complex and sulfur trioxide-triethylamine complex, at a temperature between 40.degree. and 110.degree.C, in an approprlate medium, with preference pyridine, dimethylformamide and dimethylacetamide, and final addition of aluminium hydroxychloride. This product may be used in gastrointestinal diseases. |