发明名称 |
Controlled absorption pharmaceutical formulation |
摘要 |
A controlled absorption quinidine formulation for oral administration comprises a pellet having a core of quinidine or a pharmaceutically acceptable salt thereof in association with an organic acid and optionally other excipients, and an outer membrane which permits release of quinidine in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured in a Basket Assembly according to U.S. Pharmacopoeia XXI at 37 DEG C. and 75 r.p.m. is not more than 15% after one hour of measurement. Not more than 50% of the total quinidine is release after a total of 4 hours of measurement, not more than 80% is released after a total of 8 hours of measurement and not less than 90% release is achieved after a total of 24 hours.
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申请公布号 |
US4826688(A) |
申请公布日期 |
1989.05.02 |
申请号 |
US19860930138 |
申请日期 |
1986.11.12 |
申请人 |
ELAN CORPORATION PLC. |
发明人 |
PANOZ, DONALD E.;GEOGHEGAN, EDWARD J. |
分类号 |
A61K9/30;A61K9/22;A61K9/50;A61K31/49;(IPC1-7):A61K9/22;A61K9/52 |
主分类号 |
A61K9/30 |
代理机构 |
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主权项 |
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地址 |
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