发明名称 |
UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DEL ACIDO N-GLICO-LILNEURAMINICO. |
摘要 |
PURPOSE:To obtain the titled compound useful as a precursor for production of a tumor-relating antigen determinant group and N-glycolylneuraminic acid, by reacting a specific compound with glycolic acid in the presence of dicyclohexylcarbodiimide. CONSTITUTION:The objective compound of formula III can be produced by reacting (A) methyl(methyl 5-amino-3,5-dideoxy-beta-D-glycero-D-galacto-2- nonulopyranosi-de)onate of formula I with (B) a glycolic acid (preferably the compound of formula II) in the presence of dicyclohexylcarbodiimide and preferably in the copresence of N-hydroxy-5-norbornene-2,3-dicarboximide and N- ethylmorpholine preferably in pyridine or DMF solvent. |
申请公布号 |
ES2008844(B3) |
申请公布日期 |
1989.08.16 |
申请号 |
ES19860114034T |
申请日期 |
1986.10.10 |
申请人 |
MECT CORPORATION |
发明人 |
ITO, MASAYOSHI;YOSHIMURA, SHOJI;SHITORI, YOSHIYASU;OGAWA, TOMOYA;SHIBAYAMA, SHOHEI |
分类号 |
C07H1/00;A61K31/70;A61K31/7024;A61K31/7028;A61P35/00;C07H13/04;C07H13/06;C07H15/04 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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