发明名称 |
PROCESS FOR THE PREPARATION OF 4-DEMETHOXYDAUNOMYCINONE,THE AGLYCONE OF 4-DEMETHOXY-DAUNORUBICIN |
摘要 |
4-Demethoxy-daunomycinone I: <CHEM> the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyl-daunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound with an amine, removing the amino protecting group from the resultant 4-demethyl-4-(protected amino)-13-dioxolanyl-daunomycinone, diazotising the thus-freed 4-amino group and reducing under mild conditions the resulting diazonium compound. |
申请公布号 |
ZA8901018(B) |
申请公布日期 |
1989.10.25 |
申请号 |
ZA19890001018 |
申请日期 |
1989.02.09 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
SILVIA DE BERNARDINIS;WALTER CABRI;TIZIANO MARTINENGO;FRANCO FRANCALANCI |
分类号 |
C07D317/20;C07C45/00;C07C46/00;C07C50/38;C07C67/00;C07C225/32;C07C241/00;C07C245/20;C07D317/26;C07D317/28;C07H15/252 |
主分类号 |
C07D317/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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