3-PYRROLIDINYLTHIO-1-AZABICYCLO(3.2.0)HEPTO-2-ENE-2-CARBOXYLIC ACID DERIVATIVE

摘要

NEW MATERIAL:A compound expressed by formula I [R<1> is (protected) carboxy; R<2> is (protected) hydroxy lower alkyl; R<3> is lower alkyl; R<4> is lower alkyl imidazolyl, pyridyl or lower alkyl pyrrolidinyl; R<5> is H or imino-protecting group; A is lower alkylene]. EXAMPLE:(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-[(2S,4S)-2-(1-me thyl-3- pyridiniothio)methylpyrrolidine-4-yl]thio-7-oxo-1-azabicyclo[3.2.0]hep to-2-ene-2- carboxylic acid iodide. USE:Antibacterial agent. PREPARATION:A compound expressed by formula II (reactive derivative) or salts of said compound are reacted with a compound expressed by formula III (salts).