VACCINE

摘要

A polypeptide suitable for use in a vaccine against Bordetella pertussis, B. parapertussis or B. bronchiseptica presents an epitope comprising: (a) the amino acid sequence coded for by nucleotides 1885 to 1902 of the p.69 gene of B. pertussis CN2992; (b) the corresponding amino acid sequence of another strain of B. pertussis or of a strain of B. parapertussis or B. bronchiseptica; or (c) a said sequence (a) or (b) which has been modified such that the modified sequence has substantially the same antigenicity as that of the said sequence (a) or (b); the said polypeptide being no more than 50 amino acid residues long or being a chimaeric protein having an amino acid sequence comprising the sequence of a carrier protein and a foreign sequence of no more than 50 amino acid residues which comprises the sequence of a said epitope. i