| 摘要 |
PURPOSE: To prepare a therapeutic agent specific for a tissue having a bound antigen by binding an antibody specific for the antigen and a therapeutic substance to a water-soluble polymer having no net positive charge. CONSTITUTION: This therapeutic agent comprises (A) a water-soluble polymer having a charge not greater than zero, e.g. poly(meth)acrylic acid, polyacrylamide, PVA, hydroxyethyl cellulose or a natural water-soluble polymer, (B) an antibody, bound to the component A and specific for an antigen and (C) a therapeutic substance, bound to the component A and selected from chemotherapeutic substances, radiotherapeutic substances, vitamins, tumor-inhibiting drugs and tissue affecting materials desired to be delivered to an antigenic site. The coupling of the antibody to the polymer is carried out by a binding means selected from the group consisting of an active group on the antibody, an active coupling agent, an active group on the polymer, an activable group on the polymer, a covalent bond and a biotin-avidin complex.
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