| 摘要 |
Retinoid compounds with bioactive properties and their synthesis are described. The compounds are useful as chemopreventive or cancer-treating agents and dermatological agents. The novel retinoids are members of either of the two general structures: <IMAGE> (I) or <IMAGE> (II) wherein X is CO2H or CH2OH; and in formula (I), R1 and R2 are each hydrogen, a C1-4 alkyl, a C1-4 alkoxy, or R1 and R2 taken together form a 5- to 7-membered cycloalkyl or cycloalkenyl ring; and in formula (II), R1 and R2 are each hydrogen, a C1-4 alkyl, a C1-4 alkenyl or a C1-4 alkoxy, or R2 and R3 taken together form a 5- to 7-membered cycloalkyl or cycloalkenyl with R1 and R4 being a hydrogen atom, a C1-4 alkyl, a C1-4 alkenyl or a C1-4 alkoxy. |
