FRAMEWORK MUTATED ANTIBODIES AND THEIR PREPARATION
摘要
An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species. An antibody which is capable of binding to human CD4 antigen is also provided together with a pharmaceutical composition comprising the antibody.
申请公布号
WO9205274(A1)
申请公布日期
1992.04.02
申请号
WO1991GB01578
申请日期
1991.09.16
申请人
GORMAN, SCOTT, DAVID;CLARK, MICHAEL, RONALD;COBBOLD, STEPHEN, PAUL;WALDMANN, HERMAN
发明人
GORMAN, SCOTT, DAVID;CLARK, MICHAEL, RONALD;COBBOLD, STEPHEN, PAUL;WALDMANN, HERMAN