| 摘要 |
<p>Methods and compositions for the diagnosis and prognosis of hematopoietic tumors, such as T-cell acute lymphoblastic leukemia, in a human. The invention relates to using nucleic acid hybridization probes to detect, by fluorescent in situ chromosome hybridization, deletion of tal-1 locus on chromosome 1 from human cells to confirm T-cell acute lymphoblastic leukemia in the patient. Methods and compositions for monitoring the presence of minimal residual hematopoietic tumor cells, such as T-cell acute lymphoblastic leukemia cells, in remission cells of a patient. The invention relates to using nucleic acid hybridization probes to detect alteration of tal-1 locus on chromosome 1 from a DNA extract to confirm the presence of residual T-cell acute lymphoblastic leukemia cells in the patient. Methods to quantitate the amount of hematopoietic cells are described. Kits for detecting and monitoring hematopoietic tumor cells in a patient are provided. Kits for quantitating hematopoietic tumor cells in a patient in remission are also provided.</p> |
