| 摘要 |
The invention relates to a pharmaceutical composition for the application of baclofen, in the form of an adhesive tablet, to the mucosa in the oral cavity, which pharmaceutical composition comprises a) a hydrophilic tablet core, the top surface of which adheres to the receptor surface of the oral mucosa and which contains the drug baclofen or a pharmaceutically acceptable salt thereof and, as excipients, a swellable vinyl polymer, a galactomannan and/or a pharmaceutically acceptable wax and/or a glyceride or completely or partially hydrogenated glyceride, and further optional excipients, and if, desired, b) a hydrophobic coating which covers the tablet core a), with the exception of the surface provided for the release of baclofen. The invention further relates to a process for the preparation of this adhesive tablet and the therepeutic use thereof as spasmolytic. |
