| 摘要 |
A method for making a bicyclic lactone comprising heating under aqueous acidic conditions a beta, gamma unsaturated cyclic nitrile of the formula wherein R3, R4, R5, and R6 are independently selected from the group consisting of -H, -CH3; R2 is selected from the group consisting of -H, -CH3, and -C2H5: R8 is -H or -CH3; m is an integer from 1 to 5; o is 0, 1, 2, or 3 and p is 0, 1, or 2; provided that the sum m + o + p is an integer from 3 to 5; and an aldehyde having the formula wherein R1 is selected from the group consisting of -H and -CH3, for a length of time sufficient to convert at least a portion of the reactants to a bicyclic lactone of the formula wherein R1,R2, R4, R5, R6, m, o, and p are as defined above, R3 is -CH3, or if R8 is hydrogen, R3 together with R7 represents a carbon-carbon bond, R7 together with either R3 or R8 represents a carboncarbon bond, and R8 is -H, or if R3 is -CH3, R8 together with R7 represents a carbon-carbon bond. |
